how to eliminate uric acid - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
Gout Remedy Natural Gout Treatment Treat Gouts Naturally
 

New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.


Save 40% Off The Retail Price

People Said About Goutezol Gout Treatment
"I've been suffering from gout for over 3 years. I tried many different remedies. After taking your product for 20 days I felt the difference. I'm ordering 3 more bottles to make sure I'm not going to have attack any time soon." Bill, FL
gout treatment


 HOW PEGLOTICASE WORKS

What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS

Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has been having a decent degree of success.

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

 
60-Day Risk FREE Trial

People Said About Goutezol Gout Relief
"My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY
gout treatment


In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

SIDE EFFECTS

Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

 
 
     
 
 





Learn More about Natural Gout Remedy

I get numerous e-mails from people asking if there is a cure for gout. As a natural health expert, I have to tell them "No" and "Yes". From a medical standpoint there is no declared cure for gout. However, as researched-based remedies have shown, there are gout natural remedies that can cure gout symptoms. In other words, you never have...


For years, the story of the healing benefits of the tart cherry has been the source of legend and folklore for its natural healing benefits. In addition, to the tart cherry itself, more people are swearing by the juice produced from the tart cherry to have even greater benefits natural healing benefits than the fresh tart cherry. The juice produced from the tart cherry is call by many different...


Gout is a very painful inflammatory condition of the joints, caused by crystallized uric acid collecting around the affected joint. The most common joint affected is the big toe; however, gout can affect the ankle, instep, heel, knee, spine, elbow, wrist, and finger. In severe cases, gout can deform the affected joint. People prone to gout tend to have high uric acid levels in their blood....


There seems that there is a lot of confusion as to what gout arthritis, or gouty arthritis, is because so many people just think that arthritis is arthritis and that all types are the same. But that is simply not the case at all as gout arthritis is very different from other types of arthritis. This type of arthritis is a sudden attack of extreme pain within the...


It is 2:00 a.m. You sleep soundly after savoring a scrumptious surf and turf dinner at the best restaurant in town. Suddenly an intense stinging pain caused by the soft cotton sheet resting against your big toe awakens you with a jolt! This could be an acute attack of Gout, the aftermath of a high-protein diet. No matter what Gout remedy you opt for, whether in the form of Gout's...


cherry juice good for gout | herbal supplement for gout | what foods contain purines | which foods contain purine | gout and how to prevent it | how to eliminate uric acid |







 
 
 
 
 
 
 
(c) 2015 gout-treatments.info
Contact Us | About Us | Privacy Policy | RSS Feed | how to eliminate uric acid